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R&D Pipeline
The pipelines are aiming to
Best-in-Class or First-in-Class
with great druggability and market potential
PRODUCT UNDER DEVELOPMENT
ESG401
Best-in-Class Trop2 ADC
Significant safety advantages
  • Indications

    Targeting multiple major indications, including metastatic HR+/HER2- breast cancer, triple-negative breast cancer;

    Non-small cell lung cancer, as well as various urological and gynecological tumors.

  • Development Progress

    Entered Phase III clinical trials in China.

PRODUCT UNDER DEVELOPMENT
ESG206
First-in-Class Monoclonal Antibody
Targeting the relapse and drug resistance of various B-cell malignancies
  • Indications

    B-cell malignancies, autoimmune diseases.

  • Development Progress

    Phase I dose-escalation trial in lymphoma completed;

    Well-tolerated in lymphoma patients; efficacy demonstrated in relapse and resistant lymphoma patients.

Clinical Pipelines
Drugs
Product Name
Target
Indications
Preclinical
Preclinical
IND
Phase I
Phase II
Phase III
Remarks

ADC Drugs

  • ESG401
    Trop-2
    Breast Cancer
    中国
    1

  • ESG406
    **
    GI solid tumor
    lung cancer

  • ESG407
    DLL3
    SCLC

  • ESG408
    **
    Solid tumors
    Co-developed with Foreseen Biotech, out-licensed to Ipsen

  • ESG409
    B7-H3
    NSCLC etc

  • ESG411
    Bispecific
    NSCLC etc

  • ESG412
    Bispecific
    Solid tumors

  • ESG413
    Bispecific
    Solid tumors

  • ESG414
    **

  • ESG415
    **

  • ESG416
    **

mAb Drugs

  • ESG206
    BAFF-R
    B-cell Malignancy and Autoimmune Diseases
    中国
    英国

  • ESG103
    **
    Solid tumors
    中国
    美国